16
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7019 |
Z-IETD-FMK
Z-IE(OMe)TD(OMe)-FMK,Caspase-8 Inhibitor |
Caspase | Apoptosis; Proteases/Proteasome |
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) 是一种选择性 caspase 8 抑制剂,具有细胞渗透性。它也是颗粒酶 B 抑制剂。 | |||
T10384 |
Farudodstat
ASLAN003 |
Apoptosis; Dehydrogenase; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Farudodstat (ASLAN003) 是一种具有口服活性的二氢乳清酸脱氢酶 (DHODH) 抑制剂,对人 DHODH 酶的IC50为 35 nM。它通过激活 AP-1 转录因子来抑制蛋白质合成,可以诱导凋亡,并在急性髓样白血病异种移植小鼠中大大延长其生存期。 | |||
T2065 |
Bioymifi
DR5 Activator |
Apoptosis; TNF | Apoptosis |
Bioymifi (DR5 Activator) 是一种 TRAIL 受体DR5激活剂,与DR5的胞外结构域结合,Kd 为 1.2 μM,它可诱导 DR5 聚集,导致细胞凋亡。 | |||
T6761 |
Ossirene
AS101 |
IL Receptor; Caspase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Ossirene (AS101) 是一种免疫调节抑制剂,是一种新型 IL-1beta 转化酶抑制剂,可用于自身免疫性疾病和某些恶性肿瘤。它通过抑制IL-10消除 STAT3 的磷酸化,有效抑制Caspase-1。 | |||
T6005 |
Z-DEVD-FMK
Caspase-3 Inhibitor |
Caspase | Apoptosis; Proteases/Proteasome |
Z-DEVD-FMK (Caspase-3 Inhibitor) 是一种选择性、不可逆的 Caspase-3 抑制剂,IC50为 18 μM。 它也抑制 caspase-6、caspase-7、caspase-8 和 caspase-10。 | |||
T39308 |
Boc-Asp(OMe)-fluoromethyl ketone
Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK |
Caspase | Apoptosis; Proteases/Proteasome |
Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) 是广谱的 caspase 抑制剂,可抑制 Fas 介导的吞噬作用和氧化破裂抑制,但对 IL-8 的趋化活性无影响。 | |||
T9083 |
TC11
CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 |
BCL; Caspase; CDK | Apoptosis; Cell Cycle/Checkpoint; Proteases/Proteasome |
TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) 是一种有效的肿瘤细胞增殖抑制剂,并通过激活 caspase-3、8 和 9 诱导细胞凋亡。在长时间有丝分裂阻滞期间,它诱导 MCL1降解导致凋亡。它作为苯酞酰亚胺衍生物在结构上与免疫调节药物相关。 | |||
T80093 |
IETD-CHO TFA
|
Caspase | Apoptosis; Proteases/Proteasome |
IETD-CHO TFA (Caspase-8-IN-1) 是一种高效的 caspase-8 抑制剂。 | |||
T76571 |
Caspase-8-IN-1
|
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Caspase-8-IN-1 是一种有效的caspase-8抑制剂。 | |||
T21293 |
MX1013
MX 1013,MX-1013 |
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MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9. | |||
T72435 |
Z-LE(OMe)TD(OMe)-FMK
|
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Z-LE(OMe)TD(OMe)-FMK 是一种选择性的 caspase-8抑制剂,可以抑制细胞凋亡。 | |||
T80467 |
Boc-AEVD-CHO
|
Caspase | Apoptosis; Proteases/Proteasome |
Boc-AEVD-CHO是一种Caspase 8抑制剂,适用于细胞凋亡以及免疫和炎症疾病研究。 | |||
T78586L |
Ac-IETD-CHO TFA
Ac-IETD-CHO TFA(191338-86-0 Free base ) |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Ac-IETD-CHO TFA 是一种 granzyme B 和 caspase-8 抑制剂,通过阻断 caspase3 前体裂解抑制 caspase8 活性。Ac-IETD-CHO TFA 抑制 Fas 介导的细胞凋亡(Apoptosis)。 | |||
T78586 | Ac-IETD-CHO | Apoptosis | Apoptosis |
Ac-IETD-CHO是一种针对granzyme B和caspase 8的有效可逆抑制剂,能够阻止Fas介导的(Apoptosis)、出血和肝衰竭,并且能够抑制细胞毒性T淋巴细胞引发的细胞死亡。 | |||
T69200 | CGP74514A | ||
CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and... | |||
T78855 |
Anticancer agent 157
|
NO Synthase | Immunology/Inflammation |
Anticanceragent 157(compound 15)是一种NO抑制剂,具有抗炎和抗癌特性,IC50值为0.62 μg/mL。它能够与iNOS和caspase 8结合,进而导致核断裂和染色质浓缩,从而诱导细胞凋亡。此外,Anticanceragent 157在不同癌细胞系中展现出显著的抑制活性,对HT29结肠癌细胞的IC50为2.45 μg/mL,对Hep-G2肝癌细胞的IC50为3.25 μg/mL,以及对B16-F10鼠黑色素瘤细胞的IC50为3.84 μg/mL。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2215 |
Taurochenodeoxycholic acid sodium
牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡,具有抗炎和免疫调节作用。 | |||
T2163 |
Dihydrocapsaicin
CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide |
Others; TRP/TRPV Channel | Membrane transporter/Ion channel; Others |
Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素,是TRPV1的选择性激动剂,同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。 | |||
T13815 |
Penicillic acid
|
Apoptosis; Caspase; Antibacterial; Antibiotic | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Penicillic acid, a polyketide mycotoxin, synthesized by various species of Aspergillus and Penicillium, acts as an inhibitor of Fas ligand-induced apoptosis by impeding self-processing of caspase-8. Additionally, in vitro studies have shown that Penicillic acid displays cytotoxic properties in rat alveolar macrophages. |